STAT+: Zolgensma tumor cases show risks of a common gene therapy tool

Coverage, in order

1. 6d ago
   
   first STAT Biotech indie observational

   STAT+: Novartis cites cases of previously unknown tumors possibly tied to its SMA gene therapy

   Novartis has acknowledged seven previously unknown instances in which tumors were found in children who were treated with its spinal muscular atrophy therapy, a surprising development that has raised concerns among families, physicians, and patient advocacy groups. The cases, which for the moment…

2. 5d ago
   
   STAT News indie

   STAT+: Zolgensma tumor cases show risks of a common gene therapy tool

   For two decades, researchers debated whether adeno-associated viruses (AAVs), the small viruses used to deliver new genes into thousands of patients, could in certain cases drive tumors. That debate is over. A series of cases this year has presented powerful evidence that AAVs can cause cancer…

3. 5d ago
   
   BioPharma Dive indie study observational

   Novartis reveals cancer cases possibly linked to gene therapy Zolgensma

   The occurrence of cancer in nine recipients — two of which involved evidence that a viral delivery tool integrated into patient DNA — could raise new questions for the gene therapy field.

4. 5d ago
   GEN Genetic Engineering News indie

   Novartis Confirms Nine Cases of Tumors in Children Treated with Gene Therapy Zolgensma

   Novartis has confirmed nine reports—seven of them newly disclosed—in which tumors have developed in children treated with its marketed spinal muscular atrophy gene therapy Zolgensma ® (onasemnogene abeparvovec-xioi). “Of those, two cases to date have shown evidence of vector integration into the…

5. 5d ago
   
   MedPage Today indie

   Gene Therapy Under Scrutiny After Nine Tumor Reports

   (MedPage Today) -- Drugmaker Novartis acknowledged Thursday that there have been nine reports of tumors in children treated with its gene therapy onasemnogene abeparvovec (Zolgensma) for spinal muscular atrophy (SMA). Two of the tumor cases were...

6. 2d ago
   Life Science Sweden Sweden indie

   Zolgensma gene therapy under investigation after tumour reports
7. 2d ago
   EMJ Reviews UK obscure

   FDA investigates Novartis gene therapy link to tumours in children
8. 2d ago
   
   STAT News indie study

   STAT+: Gene therapy’s long-debated cancer risk materializes

   Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. The tumors possibly connected to pediatric gene therapies make me sad. Babies. The need-to-know this morning Vir Biotechnology said monthly injections of two experimental…

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