PTHrP induces breast cancer bone metastases via microbial-dependent expansion of TNF/IL-17–producing T cells

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1. 5d ago
   JCI Insight indie study in animals

   PTHrP induces breast cancer bone metastases via microbial-dependent expansion of TNF/IL-17–producing T cells

   Bone metastases are a frequent complication of breast cancer, leading to reduced quality of life and increased morbidity. By intratibially injecting PyMT breast cancer cells in mice, we showed that the presence in the gut microbiome of segmented filamentous bacteria (SFB), a taxon that induces…

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