Shikonin alleviates bone cancer pain through suppression of spinal IGF2-associated p38 MAPK signaling

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1. 5d ago
   bioRxiv - Neuroscience obscure study

   Shikonin alleviates bone cancer pain through suppression of spinal IGF2-associated p38 MAPK signaling

   Background Bone cancer pain (BCP) is a debilitating complication of advanced cancer that substantially impairs physical function and emotional wellbeing. Current pharmacological treatments often provide incomplete analgesia and may be limited by adverse effects. Shikonin, a bioactive naphthoquinone…

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