Is metformin use associated with cognitive, physical and cardiovascular outcomes in older adults with type 2 diabetes? A secondary analysis of the SCOPE multicentre prospective cohort study

Coverage, in order

1. 2d ago
   first BMJ Open UK indie study observational

   Is metformin use associated with cognitive, physical and cardiovascular outcomes in older adults with type 2 diabetes? A secondary analysis of the SCOPE multicentre prospective cohort study

   STRENGTHS AND LIMITATIONS OF THIS STUDY This study included community-dwelling adults aged 75 years and older with type 2 diabetes from a large multicentre European cohort. The analyses accounted for kidney function and multiple clinical confounders relevant to metformin prescribing in older…

2. 2d ago
   medRxiv (all subjects) obscure study randomized trialn=19

   Effect of starting metformin on severe and long COVID-19 among people living with type 2 diabetes in England: a new user cohort study in OpenSAFELY-TPP

   Introduction: Observational studies report lower COVID-19 mortality among metformin users, but most used prevalent-user designs comparing long-term survivors with heterogeneous controls. Randomised trials suggest little or no mortality effect. No large observational study has used a new-user design…

3. 9h ago
   BMJ Open UK indie study randomized trial

   Effects of henagliflozin proline tablets versus metformin extended-release tablets on body composition in geriatric patients with newly diagnosed type 2 diabetes mellitus (HABIT-GEMs): study protocol for a multicentre, randomised, open-label trial

   STRENGTHS AND LIMITATIONS OF THIS STUDY The multicentre, randomised, open-label design incorporates blinded endpoint assessment and centralised allocation. Body composition assessments include skeletal muscle mass and fat distribution, rather than body weight alone. The multicentre randomised…

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