Complement C1q drives skeletal muscle wasting in pancreatic cancer

Coverage, in order

1. 3d ago
   Research Square obscure study

   Complement C1q drives skeletal muscle wasting in pancreatic cancer

   Cancer cachexia, defined by involuntary skeletal muscle loss, affects ~ 70% of pancreatic ductal adenocarcinoma (PDAC) patients at diagnosis and independently worsens survival. Here, we identify complement component 1q (C1q) as a driver of PDAC-induced muscle wasting, with coordinated…

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