Tetravalent dengue mRNA vaccination orchestrates balanced four-serotype immunity with durable memory and protection in mice.

Coverage, in order

1. 1d ago
   first bioRxiv - Immunology obscure study in animals

   Tetravalent dengue mRNA vaccination orchestrates balanced four-serotype immunity with durable memory and protection in mice.

   An effective dengue vaccine must establish durable immunity across four dengue virus (DENV) serotypes, evade antibody-dependent enhancement (ADE), and overcome immune imprinting from prior exposure. Here, we developed TetprM-E mRNA-LNP, a tetravalent vaccine comprising LNP-formulated…

2. 12h ago
   Research Square obscure study

   Mucosal mRNA-sLNP boosting following BCG vaccination induces local pulmonary immunity with limited inflammation

   Pulmonary vaccination improves protection against tuberculosis by generating immune responses at the primary site of Mycobacterium tuberculosis infection. However, pulmonary delivery of live vaccines can induce excessive inflammation and raises safety concerns. Here, we developed an mRNA-based…

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