The Growth Switch That Will Not Shut Off: Overactive mTORC1 Inflames Old Muscle, and Rapamycin Cannot Fully Undo It

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1. 1d ago
   
   Rapamycin News obscure in animals

   The Growth Switch That Will Not Shut Off: Overactive mTORC1 Inflames Old Muscle, and Rapamycin Cannot Fully Undo It

   Researchers at the University of Texas Health Science Center at San Antonio tested whether turning the cellular growth sensor mTORC1 permanently on is enough, by itself, to accelerate aging in skeletal muscle. They deleted Depdc5, a brake on mTORC1, in the muscle of 22-month-old mice, then aged the…

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