An AAV model of tauopathy targeting the mouse dentate gyrus reveals greater trans-synaptic tau spreading with aggregation-prone tau variants

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1. 1d ago
   bioRxiv - Neuroscience obscure study observational

   An AAV model of tauopathy targeting the mouse dentate gyrus reveals greater trans-synaptic tau spreading with aggregation-prone tau variants

   Alzheimer's disease is characterized by progressive memory and cognitive decline, which is strongly correlated with the anatomical progression of tau pathology. Resulting from the intraneuronal aggregation of misfolded tau protein, tauopathy propagates in an anterograde manner between synaptically…

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