Story · Longevity & Aging

Structural basis for repeat-associated non-AUG translation initiation on C9orf72 mRNA

1 outlet · first reported by bioRxiv - Molecular Biology 15d ago

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  1. 15d ago
    bioRxiv - Molecular Biology obscure study
    Structural basis for repeat-associated non-AUG translation initiation on C9orf72 mRNA

    A GGGGCC (G4C2) hexanucleotide repeat expansion in the first intron of C9orf72 is the most common monogenic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). This element serves as a template for repeat-associated non-AUG (RAN) translation, which generates neurotoxic…

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