Age-associated repression of HNF4α is a driver and potential therapeutic target in liver metabolic dysfunction

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1. 4d ago
   bioRxiv - Molecular Biology obscure study

   Age-associated repression of HNF4α is a driver and potential therapeutic target in liver metabolic dysfunction

   Aging is a major risk factors for metabolic dysfunction-associated steatotic liver disease (MASLD). However, the mechanisms by which aging disrupts hepatocyte transcriptional networks to drive metabolic dysfunction remain poorly understood. Hepatocyte nuclear factor 4 alpha (HNF4) is a master…

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