Story · Longevity & Aging
An aged human bone marrow mesenchymal niche causes impaired function of human hematopoietic stem cells under regeneration-induced stress
2 outlets · first reported by bioRxiv - Cell Biology 16d ago · latest 14d ago · 48 hours of coverage
Coverage, in order
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16d agoAn aged human bone marrow mesenchymal niche causes impaired function of human hematopoietic stem cells under regeneration-induced stress
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are responsible for blood formation throughout life. With advancing age, HSCs show reduced functional capacity. While clear intrinsic cellular changes in human HSCs (hHSCs) occur during aging, it remains unclear how the human bone…
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14d agoPot1a maintains mesenchymal stem cell niche function to support hematopoietic stem cells
Esaki et al. show that Pot1a preserves LepR+ MSC abundance and function by limiting DNA damage response and reactive oxygen species, thereby maintaining hematopoietic support. Pot1a deficiency impairs HSC quiescence and long-term reconstitution, whereas Pot1a supplementation improves MSC-mediated…
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14d agoFunctional Mammary Gland Organoids From Human Induced Pluripotent Stem Cells
The human mammary gland arises through sequential lineage restrictions from surface ectoderm to hormone-responsive bilayered epithelium, yet a tractable in vitro model that captures these events has remained elusive. Here, we established a stepwise differentiation protocol that directs human…
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