Pathological levels of α-synuclein increase basal mitophagy in Parkinson's dopamine neurons

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1. 10d ago
   bioRxiv - Cell Biology obscure study

   Pathological levels of α-synuclein increase basal mitophagy in Parkinson's dopamine neurons

   Elevated -synuclein results in mitochondrial dysfunction, however the exact mechanism is poorly understood. -Synuclein localises to multiple subcellular sites including mitochondria, where it binds anionic lipids which regulate mitochondrial dynamics through DRP1. We hypothesised that pathogenic…

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