Identification of Cryptococcus neoformans capsule-associated protein antigens that mediate B cell-dependent vaccine protection in mice and elicit antibody responses in humans with cryptococcosis

Coverage, in order

1. 9d ago
   first bioRxiv - Immunology obscure study in animals

   Identification of Cryptococcus neoformans capsule-associated protein antigens that mediate B cell-dependent vaccine protection in mice and elicit antibody responses in humans with cryptococcosis

   Infection with the encapsulated fungal pathogen Cryptococcus neoformans causes substantial global disease burden in persons with compromised T cell function. Previously, we demonstrated that vaccines containing adjuvanted recombinant cryptococcal proteins protected mice against lethal infection by…

2. 8d ago
   medRxiv (all subjects) obscure study

   Cross-reactive antibody and functional T-cell responses to Bundibugyo virus induced by Zaire ebolavirus vaccination and infection

   Background There is no licensed specific vaccine against the current Ebola Bundibugyo virus (BDBV) outbeak affecting the Democratic Republic of the Congo. However, clinical evaluations of a licensed Zaire ebolavirus (EBOV) vaccine have just launched. It remains unclear whether EBOV infection or…

3. 7d ago
   medRxiv (all subjects) obscure study

   Epstein-Barr virus influences the induction of protective antibody responses in young African children vaccinated with the RTS,S malaria vaccine

   The RTS,S vaccine provides moderate protection against malaria in children, which may be due in part to environmental factors. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections are prevalent in Africa and potentially contribute to suboptimal vaccine responses. We evaluated whether…

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