Story · Medicine & Biotech · Sleep

Sleep Deprivation Activates Spinal Microglia via MitoROS Mediated mtDNA-cGAS- STING Signaling to Promote Postoperative Hyperalgesia

1 outlet · first reported by Research Square 2d ago

Coverage, in order

  1. 2d ago
    Research Square obscure study
    Sleep Deprivation Activates Spinal Microglia via MitoROS Mediated mtDNA-cGAS- STING Signaling to Promote Postoperative Hyperalgesia

    Background Sleep deprivation (SD) is a major risk factor for the chronification of postoperative pain, yet the underlying mechanisms remain poorly understood. Emerging evidence indicates that mitochondrial dysfunction and innate immune signaling may contribute to central sensitization and…

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