Monomeric ASC inhibits α-synuclein aggregation through its CARD domain

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1. 2d ago
   Research Square obscure study

   Monomeric ASC inhibits α-synuclein aggregation through its CARD domain

   Synucleinopathies, including Parkinson disease, are characterized by the pathological aggregation of α-synuclein (α-syn) in the brain, which promotes neurodegeneration and inflammation. While inflammasome activation is implicated in disease progression, the direct role of the inflammasome adaptor…

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