Sleep-dependent DNA methylation remodeling in basolateral amygdala fear engrams

Coverage, in order

1. 16d ago
   Cell Reports indie study

   Sleep-dependent DNA methylation remodeling in basolateral amygdala fear engrams

   Chen et al. show that DNA methylation in memory-encoding neurons changes over weeks following learning. Sleep deprivation disrupts these changes, reducing neuronal recruitment into the memory trace and impairing memory. They identify Mid1 as a methylation-regulated gene required for fear memory…

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