Locus Coeruleus activity correlates with transient elevations in breathing during opioid-induced respiratory depression

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1. 10d ago
   bioRxiv - Physiology obscure study observational

   Locus Coeruleus activity correlates with transient elevations in breathing during opioid-induced respiratory depression

   A history of use remains a key risk factor for opioid-related overdose deaths in the ongoing opioid epidemic. The locus coeruleus (LC) is the principal source of noradrenergic tone and a site for opioid neuromodulation and tolerance. How a history of opioid use affects LC activity and shapes…

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