Revised approach for assessing obesity improves on BMI
Using data from more than 800,000 people, researchers have tested a system that can identify those with obesity who would benefit from treatment, and those who don't require intervention
Longevity & Aging · Europe
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The span that gets you out of the chair
Muscle power fades before strength or mass – for drug developers chasing muscle preservation, it might be the endpoint that matters. Lifespan, healthspan and now performancespan; the vocabulary of aging loves a span, and now it has added a new one to its lexicon, this time courtesy of Keiser , the…
Argenx pays up to $1.15b for a peptide firm
The immunology company is buying Unnatural Products to chase oral and long-acting medicines for serious immune-mediated diseases. For people with long-running immune-mediated conditions, treatment can stretch across years, so how a medicine is delivered becomes part of daily life. That is the…
MetaVia’s DA-1726 shows weight and liver fat reductions
MetaVia announced that an abstract on DA-1726, a dual oxyntomodulin analogue targeting GLP-1 and glucagon receptors, has been accepted for a poster presentation at ObesityWeek 2026 in Washington, DC. The poster, titled “DA-1726 Demonstrates Comparable Weight Loss and Distinct Metabolic Profile…
New longevity membership from L-Nutra pairs dietitians with labs
L-Nutra, Inc. launched The Longevity Program on Nov. 10, 2026, a membership that pairs each member with a dedicated Longevity Dietitian and baseline and follow-up lab testing. Membership includes access to L-Nutra’s longevity app with a trained AI guide, a 12-month curriculum covering biomarkers…
Do women with ovarian cancer live longer if poly (ADP-ribose) polymerase inhibitors (PARPi) are used in their treatment, and do PARPi cause unwanted effects?
Key messages Compared to an inactive 'dummy' medication (placebo), medications called PARPi (poly (ADP-ribose) polymerase inhibitors) given as a daily tablet for maintenance treatment (to prevent/delay cancer coming back) after chemotherapy: may increase length of life (survival) of women with…
Nya riktlinjer för vård efter skallskada
Nya skandinaviska riktlinjer ska ge stöd för hur vuxna med lindriga och måttliga skallskador ska bedömas inom akutsjukvården. Riktlinjerna bygger på en omfattande genomgång av forskningen och ska hjälpa vårdpersonal att avgöra vilka patienter som behöver datortomografi, observation på sjukhus eller…
Sju forskare vid MMK får forskningsmedel från Hjärt-Lungfonden
Vi gratulerar sju forskare vid institutionen för molekylär medicin och kirurgi som får anslag från Hjärt-Lungfondens utdelning i november 2026.
Delegation från det tyska hälsoministeriet besöker ARC för att diskutera förebyggande insatser och äldreomsorg
En delegation från Tysklands federala hälsoministerium besökte Aging Research Center (ARC) vid Karolinska Institutet den 4 november. Besöket fokuserade på hur man kan skjuta upp behovet av äldreomsorg och hur forskningsresultat om förebyggande insatser för att senarelägga behovet av äldreomsorg kan…
Fitnescity Health’s whole-body MRI scans go nationwide
Fitnescity Health opens scans at nearly 100 sites and offers them to health platforms through a single API. A whole-body MRI has been mostly a boutique experience. Fitnescity Health , which calls itself the largest US network of preventive imaging, is trying to make it something you can book like a…
The first longevity protocol engineered for all 14 hallmarks of aging
TimeWarp Longevity Protocol combines 25 compounds, a monthly senolytic reset and an app – one system built around the 2025 hallmarks update. By Wednesday, half the pills are usually still sitting in the organizer. That is how TimeWarp ’s founder describes the typical serious longevity routine: a…
What terrifying sleep paralysis demons reveal about the mind-body connection
After waking with the feeling of a shadowy presence pressing on his chest, neuroscientist Baland Jalal went on to study sleep paralysis. He explains what this frightening condition might reveal about consciousness
Humacyte begins first-in-human coronary bypass trial
Humacyte has initiated a Phase 2a clinical study of its investigational coronary tissue-engineered vessel, CTEV, in patients undergoing coronary artery bypass grafting, and the study is now open for enrollment. The FDA accepted Humacyte’s investigational new drug application in July 2026, and the…
Podd-tips: Nya behandlingar vid bukspottkörtelcancer
Nya forskningsresultat kan förändra behandlingen av bukspottkörtelcancer. I ett nytt avsnitt av Karolinska Universitetssjukhusets podd "Kliniskt sett" diskuteras nya behandlingsmöjligheter och vad de kan innebära för framtidens cancervård.
Opioidanvändning kan bli långvarig efter operation
Runt 7 000 patienter per år i Sverige som inte tidigare använt opioider fortsätter att hämta ut läkemedlen flera månader efter en operation, vilket ökar risk för beroende, enligt en ny doktorsavhandling från Karolinska Institutet. Den visar också att mängden opioider efter större kirurgi kan…
The senescent macrophage as a central hub in skeletal aging: Mechanisms, niche disruption, and systemic consequences
Publication date: January 2027 Source: Ageing Research Reviews, Volume 123 Author(s): Zhe Li, Ying Li, Lei Sui, Chufan Ma
Cold therapy may be worse than doing nothing for post-exercise recovery
Many are convinced that ice baths or cold showers are an effective way to speed recovery after exercise, but a study finds that cold therapy may actually have the opposite effect
500 people, six months, one goal: Reverse aging
From brain scans to Super Mario, NeuroAge and TruDiagnostic explain how Younger turns personal health goals into public science. Ask a stranger what they know about longevity, and Dr Christin Glorioso says you’ll probably get one name back: Bryan Johnson. That, she told Phil Newman on…
X chromosome gene may reduce autism rates in women and girls
A gene called ZFX exerts powerful effects on an entire network of genes linked to autism, which may help explain why the condition is less common in females
Sironax selected for two ObesityWeek 2026 abstracts
Sironax announced that two abstracts on its NAMPT activator SIR4156 were selected for poster presentations at ObesityWeek 2026, the Obesity Society annual meeting scheduled Nov. 14–17 at the Gaylord National Resort and Convention Center in National Harbor, Maryland. Both posters are scheduled in…
Insilico open-sources Longevity Grok personal longevity AI
Insilico Medicine announced the open-source release of Longevity Grok, described as the Personal Longevity Superintelligence (PLSI), developed for the Grok Bot platform in collaboration with geroscience researcher David Sinclair. The company claims PLSI is a multi-agent system that unifies…
BioCardia completes PMDA consultations for CardiAMP in Japan
BioCardia has completed the clinical consultation process with Japan’s Pharmaceuticals and Medical Devices Agency for the CardiAMP Cell Therapy System, moving toward submission of a marketing approval application. CardiAMP is intended to offer patients with ischemic heart failure a minimally…
Metavia interim data show 68% liver fat reduction
MetaVia released interim Part 3B results from its Phase 1 trial of DA-1726, a once-weekly oxyntomodulin analog that targets GLP-1 and glucagon receptors, showing a 68% placebo-adjusted reduction in liver fat and a 13.5% placebo-adjusted body weight reduction after 16 weeks. The MRI substudy…
Elysium Health expands access to six peptides
Elysium Health announced plans to offer six additional peptides—BPC-157, Epitalon, KPV, MOTS-c, Semax and TB-500—through Elysium Health Rx under a new interim enforcement-discretion policy issued by the U.S. Department of Health and Human Services. The company announced the launch of the Elysium…
Hyperbaric oxygen therapy and cardiorespiratory fitness: the strongest prognostic markers of health and ageing improve across more than 1,000 patients, consistent with controlled trials
IntroductionCardiorespiratory fitness (CRF), assessed via cardiopulmonary exercise testing (CPET), is a powerful objective marker associated with biological aging, healthspan, and all-cause mortality. Controlled trials have reported improvements in CRF following hyperbaric oxygen therapy (HBOT)…
Engineering ATP import in yeast uncovers a synthetic route to extend cellular lifespan
Mitochondrial dysfunction and declining ATP production are common features of aging, yet whether ATP availability itself directly regulates cellular lifespan is unclear. However, the causal relationship between cellular ATP homeostasis and aging has not been established. Here, we developed a…
AI kan hitta viktig information i bilder av bröstcancer
Artificiell intelligens (AI) kan hitta information om bröstcancer och patienters prognos i digitala bilder av tumörvävnad. Det visar en ny doktorsavhandling från Karolinska Institutet. Resultaten tyder på att vävnadsprover som redan används i vården innehåller mer information än vad som tas till…
När elitidrotten möter forskningen
Hur kan elitidrottare prestera och samtidigt hålla över tid? När KI deltog i höstens Coachforum på Limnos möttes forskning och tränarnas erfarenheter. Carl Johan Sundberg ser tränarna som en nyckel till att kunskapen ska nå flera generationer aktiva.
Avhandling undersöker läkemedelsbehandlingar för att förebygga bröstcancer
I en ny avhandling beskriver Mattias Hammarström de studier som han och det forskarteam han ingår i har genomfört av läkemedlet tamoxifen och en av dess mest aktiva nedbrytningsprodukter (metaboliter), endoxifen. Målet har varit att undersöka om låga doser av tamoxifen minskar biverkningar och hur…
David Freiholtz får Viking Olov Björk-priset
Vi gratulerar David Freiholtz som tilldelades Viking Olov Björk-priset för bästa Avhandling inom Thoraxkirurgi vid Thoraxmötet i Lund den 5 november 2026. Davids avhandling "Ascending aortic aneurysm : implications of aortic valve phenotype" har handletts av Hanna Björck vid institutionen för…
Klusterhuvudvärk kopplad till uttalade utmattningssymtom
Personer med klusterhuvudvärk upplever ofta mer än bara intensiv smärta. En ny studie från Karolinska Institutet, publicerad i Headache, tyder på att många även rapporterar symtom på utmattning, särskilt under perioder då huvudvärksattackerna är frekventa. Resultaten understryker vikten av att ta…
Hur mitokondrier håller proteinproduktionen igång
Forskare vid Karolinska Institutet har upptäckt hur proteinet TACO1 hjälper mitokondrier att producera proteiner när processen stöter på svårbearbetade sekvenser. Studien, som publicerats i Nature Communications, ger nya insikter i en mekanism som är störd vid vissa mitokondriella sjukdomar.
Variation i bröstcancer kopplas till metastasrisk och behandling
Variationer inom brösttumörer och mellan patienter hänger samman med risken för metastaser och nyttan av antihormonell behandling. Det visar en ny doktorsavhandling från Karolinska Institutet. Resultaten visar också att lång uppföljning är viktig för att fånga behandlingens långsiktiga nytta.
Effects of Probiotics/Synbiotic Interventions on Cognitive Dysfunction in Alzheimer's or MCI: A Systematic Review and Meta‑Analysis of randomized controlled trials
Publication date: Available online 9 November 2026 Source: Ageing Research Reviews Author(s): Mengyu Zhang, Haoyue Zhang, Bingmeng Fu, Dengfeng Xu
#626: Practical Diet Considerations for Healthy Aging - Prof. Charlyn Black
Living longer does not necessarily mean spending more years in good health. But how much of the decline we associate with aging is inevitable, and how much reflects disease, inactivity, and other potentially modifiable factors Nutrition presents a particular challenge in later life: energy…
Astrocyte-independent Aβ-induced tauopathy in a 3D culture model of Alzheimer’s disease
Astrocytes are essential for neuronal health, and astrocyte reactivity is a hallmark of neuroinflammation, a key regulator of Alzheimer’s disease (AD) pathology. Despite increasing evidence linking neuroinflammation and astrocyte reactivity to AD, the precise role of astrocytes in disease…
Idiopathic normal pressure hydrocephalus: from pathophysiological mechanisms to precision diagnosis and optimized therapeutic outcomes
BackgroundIdiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurological disorder of older adults, characterized by the classic triad of gait disturbance, cognitive impairment, and urinary incontinence. Despite its treatable nature, iNPH remains widely underdiagnosed, and…
From bison powder to a £30,000 robot that massages you, our expert guide to which new products really WILL help you live longer
What's the best way to stave off ageing? To find out the latest thinking, thousands of 'biohackers' - seeking to optimise their health - poured through the doors at a summit in London.
Från kunskap till praktisk kompetens – Olle ten Cates idéer fick global spridning
Med konceptet EPA har professor Olle ten Cate förändrat läkarutbildningar världen över. För sin banbrytande forskning tilldelades han 2026 års KIPRIME, Karolinska Institutets pris för forskning i medicinsk pedagogik. Men från början var det långt ifrån självklart att han skulle ägna sig åt…
Blood pressure phenotypes and kidney impairment in adults with diabetes: a machine learning study
BackgroundDiabetic kidney disease (DKD) is a leading cause of end-stage renal disease, with hypertension being a key modifiable risk factor. However, associations between specific blood pressure (BP) phenotypes and concurrent DKD risk remain poorly understood.MethodsThis cross-sectional study…
Welfare fraud is changing how elder-care case workers workVälfärdsbrott förändrar biståndshandläggarnas arbete
Welfare crime has become part of daily life in elderly care; case workers increasingly spend their time detecting fraud and vetting providers.Välfärdsbrottslighet har blivit en del av vardagen inom äldreomsorgen. Biståndshandläggare får allt oftare ägna arbetstid åt att upptäcka fusk och granska utförare i stället för att fokusera på äldres omsorgsbehov. Det visar en studie. Forskare vid Södertörns högskola har undersökt hur…
The lie of the land: dog lifespans track human mortality by state
Analysis of 41,000 companion dogs finds they share a mortality map with people – and a rural penalty that is really a matter of size. A giant dog in Oklahoma and a small one in Hawaii are not, it is fair to say, running the same race. Size accounts for most of the gap; breed and sex for a little…
Less than 4 minutes of vigorous exercise a day could halve your dementia risk
Bursts of vigorous physical activity, such as carrying heavy shopping or rushing for the bus, seem to have a significant effect on our brain health and dementia risk
Parkinson’s may be driven by ‘vicious cycle’ that disrupts brain waste drainage
Parkinson's disease is linked to toxic protein clumps and disrupted brain waste removal, which may feed off each other, causing the condition to progress
Italy's dementia plan makes room for Bruce Willis's diseaseC’è un posto nel piano demenze per la malattia di Bruce Willis
Patient families: 'At last a light on FTD and little-known early-onset forms, but visibility must translate into timely diagnosis and dedicated care pathways.'Le famiglie pazienti dei: “Finalmente si accende una luce su Ftd e forme giovanili poco conosciute, ma visibilità si traduca in diagnosi tempestive e percorsi dedicati”
Epigenetics may be aging’s biggest speed limit
A new review argues that aging has several brakes, not one, and that the way genes are switched may hit the limit first. Clone a mouse from a mouse from a mouse, and somewhere around the 27th generation things start to go wrong. Efficiency drops. By the 58th generation, the whole thing collapses. A…
Resolution Therapeutics posts positive interim EMERALD results
Resolution Therapeutics announced positive interim six-month results from its Phase I/II EMERALD trial of RTX001 in end-stage liver disease. The analysis compared the first nine of 15 treated patients to 21 standard-of-care patients in the OPAL external control and found a 42 percent relative risk…
‘No Evidence’ It Will Make You Live Longer: Inside Abu Dhabi’s Rush to Sell the Science of Ageing
A painkiller designed by artificial intelligence that beat morphine in animal tests; a “biological age” score on a government app. Smart-ring makers fighting each other in court while signing deals with the same health department. At its Future Health Summit, Abu Dhabi showed how hard it is to bet…
Ageing: why do muscles lose their ability to repair?Vieillissement : pourquoi les muscles perdent-ils leur capacité à se réparer ?
With age, muscles recover less well after injury. An Inserm team in Illkirch has uncovered a mechanism behind it.Avec l’âge, les muscles récupèrent moins bien après une lésion. À Illkirch, une équipe Inserm de l’Institut de génétique et de biologie moléculaire et cellulaire vient de mettre en lumière un mécanisme qui pourrait contribuer à ce phénomène. Grâce à des travaux menés chez la souris, elle montre en…
'This vaccine can cut dementia risk by up to 20 percent'„Mit dieser Impfung lässt sich das Demenzrisiko um bis zu 20 Prozent senken“
Flu, herpes, inflamed gums: even everyday infections can raise dementia risk. Andrea Pfeifer explains which viruses attack the brain and what helps.Grippe, Herpes, entzündetes Zahnfleisch: Selbst alltägliche Infektionen können das Demenzrisiko nachweislich erhöhen. Andrea Pfeifer kennt die Viren, die das Hirn angreifen. Diese Maßnahmen empfiehlt die Toxikologin.
KI:s masterprogram i toxikologi firade 50 år
Över 250 alumner, nuvarande och tidigare lärare, studenter och samarbetspartners samlades på Karolinska Institutet den 24 oktober för att fira 50-årsjubileet för masterprogrammet i toxikologi. Genom presentationer och reflektioner från tidigare studenter verksamma inom akademi, industri…
Age-Related Disruption of Endoplasmic Reticulum Homeostasis in Leydig Cells: Mechanisms of Declining Testosterone Biosynthesis and Potential Therapeutic Strategies
Publication date: Available online 7 November 2026 Source: Ageing Research Reviews Author(s): Meng Yuhao, Ning Gang, Wu Hui, Wang Haoyu, Liu Wei, Yang Chun, Yang Yang, Li Bonan, Jian Mintao, Zhou Xing
Could implanted cells serve as a Klotho factory?
A Frontiers in Aging perspective pitches encapsulated cells as a steady source of the antiaging protein, framed as a proposed solution. Klotho is named after the mythological spinner of life’s thread, which is a lot to live up to. The gene was discovered in 1997 by Kuro-o and colleagues, and when…
RoC turns to identical twins, Oura data to investigate skin aging
RoC is recruiting at least 30 pairs of women 40 and older for a 12-week study that pairs skin checks with sleep and stress data. Twins wanted. RoC Skincare is recruiting at least 30 pairs of adult female identical twins, aged 40 and older and living in the US, to test a regimen built around its…
Why decentralized longevity trials live or die by data architecture
Designerly’s Cooper Adwin on why regulatory governance and secure data architecture are critical for longevity biotech. Decentralized longevity trials put data infrastructure on the critical path to clinical validation. Tracking a biomarker endpoint across research sites and jurisdictions requires…
Oulu city podcast: new hope for Alzheimer's prevention. Do nitrates and vibration clean the brain?Kaupunkipodi Oulu: Alzheimerin ehkäisyn uusi toivo – puhdistavatko nitrot ja tärinä aivoja?
The new episode discusses a study that has drawn attention in research circles worldwide.Kaupunkipodi Oulun uudessa jaksossa käsitellään tutkimusta, joka on herättänyt huomiota tutkijapiireissä ympäri maailman.
Viome Acquires Sōlaria Biō to Launch Clinically Validated Consumer Synbiotics and Medical Foods
The acquisition marks Viome’s latest step in expanding its personalized health platform following its acquisition of Circulate Health , further …
Humanaut Health expands with six new locations
Humanaut Health announced six new franchise and corporate locations across the United States and Mexico. The rollout includes a Humanaut Stem Cell Center of Excellence in Park City, Utah, planned openings in Palm Desert, California and Park City in November 2026, a San Antonio clinic expected to…
University trial finds NOVOS Core improved vascular health measures
A randomized, double-blind, placebo-controlled trial led by Professor Christian Heiss at the University of Surrey reported that six months of daily NOVOS Core improved blood vessel function, arterial flexibility and systolic blood pressure in healthy adults aged 40 and older. The STAMINA trial…
The longevity secret of 106-year-old Italian Gianna Pratesi: 'I sleep a lot and eat two ice creams a day'El secreto de la longevidad de la italiana Gianna Pratesi, de 106 años: "Duermo mucho y como dos helados cada día"
Sleeping a lot must be one of the secrets of longevity. So, apparently, is eating two ice creams a day. At least that is the recipe Gianna Pratesi, a 106-year-old Italian woman, revealed shortly after her birthday.Dormir mucho debe ser uno de los secretos de la longevidad . Y comer dos helados al día, también. Al menos, esa es la receta que Gianna Pratesi , una mujer italiana de 106 años , desveló poco después del festival de Sanremo, cuando saltó a la fama al recordar cómo fue su primer voto en las…
Interhemispheric M1-M1 connectivity and resilience against basic motor function decline in aging
Publication date: Available online 6 November 2026 Source: Neurobiology of Aging Author(s): Felix Wullenkord, Michella Bardakan, Veronika Wunderle, Taylan Kuzu, Christian Grefkes, Peter H. Weiss, Gereon R. Fink
Immunosenescence in radio-immunotherapy: From biological mechanisms to therapeutic opportunities?
Publication date: January 2027 Source: Ageing Research Reviews, Volume 123 Author(s): Shaochuan Liu, Liuze Li, Deyi Zhang, Zhenzhen Yin, Yong Guan, Zhiyong Yuan
Ageing and Platelet-Rich Therapies: Biological Determinants of Regenerative Potential
Publication date: Available online 6 November 2026 Source: Mechanisms of Ageing and Development Author(s): Eduardo Anitua, Roberto Tierno, Mohammad Hamdan Alkhraisat
Multi-tissue metabolomic signatures of five longevity interventions converge on ergothioneine and lipid remodeling in male UM-HET3 mice
IntroductionThe pace of aging can be delayed by mutations, dietary manipulations, and drugs, yet the metabolic mechanisms underlying longevity interventions remain poorly understood.MethodsHere we present a multi-tissue metabolomic analysis of male UM‐HET3 mice treated from 4 to 12 months of age…
Laboratory and clinical frailty indices identify distinct patterns of vulnerability across the adult age range in the Novara cohort study
BackgroundFrailty may involve biological dysregulation that precedes, accompanies, or occurs partly independently of clinically expressed deficits. Laboratory and clinical frailty indices quantify vulnerability through different sets of deficits, but whether their divergence reflects measurement…
Accelerated immune senescence in people living with HIV: a systematic review of mechanisms, biomarkers and implications for healthy aging
BackgroundDespite effective antiretroviral therapy (ART), many people living with HIV (PLWH) exhibit persistent immune dysfunction associated with premature biological aging. This review synthesized evidence on the mechanisms, biomarkers and clinical implications of HIV-associated…
The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit
A coordinated response to stress is crucial for promoting the short- and long-term health of an organism. The perception of stress, frequently through the nervous system, can lead to physiological changes that are fundamental to maintaining homeostasis. Activating the response to low oxygen, or…
Healthy aging, processing speed, and mnemonic brain state engagement
Publication date: Available online 5 November 2026 Source: Neurobiology of Aging Author(s): Hannah R. Buras, Subin Han, Nicole M. Long
Circulating cell-free DNA and plasma nuclease activity in human aging
Publication date: Available online 4 November 2026 Source: Mechanisms of Ageing and Development Author(s): Elizaveta Ershova, Pavel Umriukhin, Julia Chudakova, Roman Veiko, Tatiana Salimova, Nataly Veiko, Alexey Moskalev
Metabolomics-guided structure-based virtual screening prioritizes obtusifolin as a geroprotector in Caenorhabditis elegans
Publication date: Available online 4 November 2026 Source: Mechanisms of Ageing and Development Author(s): Jun Liu, Yuting Ding, Kang Li, Chenxi Zhou, Yanan Zhao, Yongtao Cheng, Yichen Liu, Chuanyue Peng, Kang Shan, Wenjing Yan, An Xu, Min Zuo, Ying Liu
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