Longevity & Aging · North America
Making China longevity-ready: the current and future economic benefits of investing in prevention
This report, Making China longevity-ready: the current and future economic benefits of investing in prevention, explores the current and future economic contributions of older people and examines how greater investment in prevention could help China unlock the longevity dividend.
Upfront PCI Still Not Beneficial for Stable CAD as Far Out as 25 Years
(MedPage Today) -- A longer horizon did not give patients with stable coronary artery disease (CAD) any improved hard outcomes when getting an invasive strategy over conservative management, according to extended results from the COURAGE and ISCHEMIA...
Older adults aging where they choose: Possibility or illusion?
Canadians aged 65 and older want to decide where they live and most prefer that place to be their current home . The concept of an older adult aging in the place of their choosing emphasizes that preference. Preference, however, does not guarantee that aging in that place will be possible…
Late Life Asparagine Endopeptidase Inhibition Extends Lifespan in Mice
Few interventions have been demonstrated to slow aging or address age-related damage to a sufficient degree to extend mouse life span by 15% or more if applied starting at a late age. The requirement to start late in life cuts down the field of possibilities quite dramatically. Today's open access…
Free Tools & Resources for New Research Leaders (2026)
Free Tools & Resources for New Research Leaders (2026) Dementia Researcher Dementia Researcher Most new research leaders got there by being good at research. Then the job changes. Suddenly you are hiring people, managing a budget and writing appraisals. You have to decide the order of an author…
The Short Peptide Elamipretide Delays Ovarian Aging in Mice
A recent study showed that a treatment with the short peptide elamipretide reversed multiple signs of age-related decline in oocyte quality in mice and in human oocytes in vitro [1]. An early decline In females, the reproductive system ages relatively early in life, with fertility declining as…
What the VA Gets Right About Death
(MedPage Today) -- On November 11, 1991, I called my father, a taciturn 24-year senior non-commissioned officer, to wish him a happy Veterans Day. I was a newly minted second lieutenant, and his pride in my becoming an officer and first-generation...
How to Secure Your First Postdoc Role
How to Secure Your First Postdoc Role Dementia Researcher Dementia Researcher Thinking about your first postdoc, or already applying? In September, jobs.ac.uk ran a free webinar on exactly that, hosted by Katie Hoare , a careers and employability skills specialist for postgraduate and early career…
Exercise vital for improving brain health across the lifespan
ORLANDO — Across a person’s life, exercise plays a critical role by treating and strengthening many aspects of mental and behavioral health, according to a speaker. During a keynote presentation at the American College of Lifestyle Medicine’s annual meeting, John J. Ratey, MD, an associate clinical…
Two Biologics for Psoriatic Arthritis Square Off in Big Trial
(MedPage Today) -- ORLANDO -- A large head-to-head trial reported here that pitted bimekizumab (Bimzelx) against risankizumab (Skyrizi) as treatment for psoriatic arthritis (PsA) yielded a winner, albeit with a couple caveats. Arthritic symptoms...
Rheumatoid Arthritis Does Not Improve the Menopause Experience
(MedPage Today) -- ORLANDO -- Women with rheumatoid arthritis (RA) had a worse menopause experience compared with the non-RA individuals going through the transition, a researcher reported here. Symptom severity, as evaluated with the Menopause...
Tel Aviv University Honors Extraordinary Leaders in Science, Culture, Philanthropy and the Human Spirit
An evening of inspiration, gratitude and powerful reunions marked Tel Aviv University's 2026 Honorary Degrees Ceremony, held at the Smolarz Auditorium as part of the University's 70th anniversary celebrations. Distinguished scientists, philanthropists, artists and educators from Israel and around…
Failure of Protein Quality Control Mechanisms in Muscle Aging
A cell is a bag of finely tuned molecular machinery moving at incredible speeds, pieces of that machinery ramming into one another countless times per second. Damage occurs constantly, a matter of inappropriate chemical reactions, broken proteins, misfolding of proteins, the machinery degraded and…
Calibrating Effects of a Novel Supplement Strategy on Vascular Measures of Aging
The supplement industry exists in its present vocal form because most people don't care about effect size at all. Or accuracy. Or truth. They hear that something has an effect, and run out to buy it. The industry marketing is tuned to take advantage of this aspect of human nature. But what are the…
Suggest a Paper for the 2027 ISTAART Year in Review Webinars
Suggest a Paper for the 2027 ISTAART Year in Review Webinars Dementia Researcher Alzheimer's Association ISTAART is asking the research community which papers should feature in its 2027 Year in Review webinars, where each Professional Interest Area (PIA) looks back at the standout research of 2026…
Correction: Participatory insights into ageing and care: a qualitative study of South Asian and Muslim communities
Zeibeda Sattar, Nazrul Hussain, Sheinaz Stansfield. Participatory insights into ageing and care: a qualitative study of South Asian and Muslim communities. This abstract was amended after publication to remove two individuals from the author list. Hayley Alderson and Ruth McGovern have been removed…
Clownfish put anemone home before social group when bleaching strikes
Marine heatwaves and anemone bleaching are altering clownfish behaviour, making clownfish more defensive of their host and more aggressive towards one another, new research reveals.
HealthSpan Partners ups Surgery Partners offer to $6B after rival bid
Bon Secours’ affiliate HealthSpan Partners is offering $300 million more for Surgery Partners as competition for the extensive surgical care network heats up with a rival bid.
PAHO calls for stronger menopause care to promote healthy aging in the Americas
PAHO calls for stronger menopause care to promote healthy aging in the Americas Oscar Reyes 10 Nov 2026
Evidence for Cerebrospinal Fluid Flow Through the Brain to Stagnate in Alzheimer's Disease
Cerebrospinal fluid flows through the brain and out into the body, particularly during sleep. One of the important functions of this drainage of cerebrospinal fluid is the removal of metabolic waste from brain tissue. This waste material includes the pathological protein aggregates implicated in…
When a Gun Owner Shows Early Signs of Dementia
(MedPage Today) -- If you or someone you know may be experiencing a mental health crisis, contact the 988 Suicide & Crisis Lifeline by dialing or texting "988." He was 72, a retired health administrator who lived alone near Seattle. Laura...
A Supplement Kills Senescent Cells and Extends Life in Mice
A new study shows healthspan and lifespan increases in male mice following late-life treatment with vanadyl sulfate, a food-derived molecule marketed as an over-the-counter supplement [1]. Searching for vulnerabilities Cellular Senescence As your body ages, more of your cells become senescent…
Profile – Dr Keeley Brookes, Nottingham Trent University
Profile – Dr Keeley Brookes, Nottingham Trent University Dementia Researcher Dementia Researcher Dr Keeley Brookes Name: Dr Keeley Brookes Job title: Associate Professor Place of work/study: Nottingham Trent University Area of Research: Genetics & genomics of dementia genetics gene expression…
University partners with industry on biofilm innovation projects
Newcastle University has secured funding for two collaborative research projects through the National Biofilms Innovation Centre’s (NBIC) Industrial Challenge Response Fund (ICRF).
$32 million NIH grant expands decades-long Alzheimer’s study
When Leonard Berg, MD , then a neurologist at Washington University School of Medicine in St. Louis, noticed memory problems among his older patients in the 1970s, he refused to dismiss the problems as part of “normal aging” or senility but instead set out to understand what was happening in their…
Tetravalent dengue mRNA vaccination orchestrates balanced four-serotype immunity with durable memory and protection in mice.
An effective dengue vaccine must establish durable immunity across four dengue virus (DENV) serotypes, evade antibody-dependent enhancement (ADE), and overcome immune imprinting from prior exposure. Here, we developed TetprM-E mRNA-LNP, a tetravalent vaccine comprising LNP-formulated…
Blog – Do We Already Know What Good Care Looks Like?
Blog – Do We Already Know What Good Care Looks Like? Dementia Researcher Adam Smith I’ve been going to dementia conferences for about 20 years now. My career has been in healthcare and service improvement, so I tend to sit there listening to the science while wondering how any of it would actually…
Identifying Hormetic Agents that Modestly Slow Aging from Mouse Toxicology Study Data
Regulatory systems in wealthier parts of the world ensure that a great many different compounds at different doses are entered into long-term toxicology studies primarily conducted in mice. Researchers here report on the results of looking through that data in search of compounds that improved…
Cepharanthine Identified as a Novel Senolytic
Senescent cells accumulate with age and generate inflammatory secretions that are disruptive to tissue structure and function. Targeted clearance of some fraction of these lingering senescent cells in aged tissues via senolytic therapies has been shown to reverse aspects of aging and extend life in…
FameLab UK 2027: Applications Now Open
FameLab UK 2027: Applications Now Open Dementia Researcher Dementia Researcher Could you explain your research in three minutes, with no slides? FameLab UK, the science communication competition run by Cheltenham Festivals, is open for 2027 entries. It comes with free training, a chance to perform…
When a Gun Owner Shows Early Signs of Dementia
If you or someone you know may be experiencing a mental health crisis, contact the 988 Suicide & Crisis Lifeline by dialing or texting “988.” He was 72, a retired health administrator who lived alone near Seattle. Laura Prater, a firearms researcher at Ohio State, was interviewing him via Zoom…
Climate expert warns UK must prepare for increasingly extreme weather
Newcastle University climate expert warns UK faces increasingly extreme weather due to fossil fuel burning, as public calls for urgent action.
Newcastle discovery featured in new stamp collection
A discovery made during an archaeological excavation that involved students at Newcastle University has been commemorated in a new stamp collection.
Speak at the Salon: 2027 Schedule Now Open
Speak at the Salon: 2027 Schedule Now Open Dementia Researcher Dementia Researcher We’re opening submissions for the next season of the Dementia Researcher Salon Showcase , running from January through April, and we want to hear from you. The Salon is our space for early career researchers to share…
Longevity Drugs: Perceived Efficacy Outweighs Risk & Every Ethical Objection Roughly Ten to One
Researchers at Singapore Management University and the National University of Singapore ran a preregistered, door-to-door national survey of 2,003 Singapore adults to find out who would take a repurposed chronic-disease drug, framed as a health optimization medication, and why. The answers were…
One Small Patch of Living Muscle Improved Strength, Bone, Liver and Memory in Old Mice
Researchers at the Chinese Academy of Sciences took muscle stem cells from a mouse’s own thigh, grew and differentiated them in culture, then injected the resulting myocytes under the skin of the animal’s back. The cells organized into vascularized, mature muscle tissue that contracted…
Neuromelanins: a link between brain aging and neurodegenerative diseases
Physiological Reviews, Ahead of Print.
Beyond Exercise: How Movement Can Build Self-Trust — A Physician’s Take
Dr. Em Wong is a doctor of internal medicine and brain health coach with a background in women’s health and integrative medicine. An artist and author of iHeal Mag online, she is writing a book, “Vibrant to 100: Extend Your Brainspan and Shape How You Age.” Her goal is to be healthy of mind and
The people who only need four hours' sleep (BBC)
Some people really are fine with remarkably little sleep. But it can be hard to tell if you’re one of those people. For as long as she can remember, Aimee Pugh Bernard hasn’t needed much sleep. Today she tends to go to bed around 22:00 and wake up around 04:30. “I’m wide awake. I cannot stay in…
GERI‐RISK: A Quality Improvement Initiative to Screen for Social Risk in a Geriatric Care Clinic
ABSTRACT Background Unmet social determinant of health (SDOH) needs can impede access to healthcare and increase morbidity and mortality for older adults. Screening for SDOH takes time, and primary care clinicians often have competing demands. Methods Using a quality improvement (QI) approach, we…
The Growth Switch That Will Not Shut Off: Overactive mTORC1 Inflames Old Muscle, and Rapamycin Cannot Fully Undo It
Researchers at the University of Texas Health Science Center at San Antonio tested whether turning the cellular growth sensor mTORC1 permanently on is enough, by itself, to accelerate aging in skeletal muscle. They deleted Depdc5, a brake on mTORC1, in the muscle of 22-month-old mice, then aged the…
Diet Quality Versus Physical Activity and Cardiorespiratory Fitness for Longevity: A Review of Comparative Evidence
Poor diet quality and insufficient physical activity (PA) are major modifiable risk factors for chronic disease and a shortened lifespan. Public health priorities have historically emphasized dietary modification more than increasing PA, and this disproportionate emphasis persists in current…
Smartwatch Detection of Reduced LVEF? Not So Fast, Study Says.
(MedPage Today) -- The enthusiasm for smartwatch detection of left ventricular systolic dysfunction (LVSD) was tempered by a Korean study indicating difficulties with the technology in its current state. Using an artificial intelligence (AI)-ECG...
Win a SmartSocks DISCOVERY Kit for Your Research
Win a SmartSocks DISCOVERY Kit for Your Research Dementia Researcher Dementia Researcher Got an idea for a study that needs continuous physiological or movement data, but no kit to collect it? Milbotix has opened its SmartSocks®DISCOVERY Pioneers Competition 2026, offering wearable research kits to…
What do we know about the biological factors behind women's longer average lifespan?
Women tend to live longer than men on average in many populations, but the reasons appear to involve a combination of biological, behavioral, and social factors. I've been interested in how researchers separate the potential contributions of sex chromosomes, hormonal signaling, immune function…
HELP: analyse blood report
I’ve been taking rapamycin for a little over two years. I’m a 36-year-old male, and I take 6 mg of rapamycin once a week and 30 mg of empagliflozin daily. I’m not a picky eater, and I eat meat and drink milk every day. After taking rapamycin for some time, I started experiencing persistent coldness…
Machine Learning–Based Biomechanical and Clinical Assessment of the Five Times Chair Rise Test in Older Adults: Sensor-Based Functional Aging Study
Background: Maintaining functional ability is essential for healthy aging. The Five Times Chair Rise Test (5CRT) is widely used to assess lower-extremity function, yet conventional stopwatch timing provides limited insight into movement quality and compensatory strategies. Sensor-based biomechanics…
Water Fluoridation Does Not Impair Brain Function
Summary: A population-based epidemiological investigation from Trinity College Dublin finds no evidence connecting lifetime exposure to fluoridated drinking water with cognitive decline or dementia risk in older adults. Published in the Journal of Dental Research, the study analyzed 2,495 adults…
An Introduction to Mechanisms of Aging and the Treatment of Aging
Writing a succinct few page introduction to present scientific thought on the driving mechanisms of aging and the present landscape of development of means of treating aging seems quite the tall order. The field is complex, aging is complex, much is in flux and important updates to present…
From Alveoli to Mitochondria: Respiratory and Aerobic Reserve as Therapeutic Targets in Longevity Medicine
Longevity medicine seeks to extend both lifespan and healthspan, the years in which people can climb stairs, recover from illness, and live independently. Respiratory function and aerobic capacity contribute to these goals through different components of oxygen transport, yet their prognostic…
Inflammaging and Poor Sleep Contribute to One Another
After a review of substantial literature, scientists publishing in Aging Cell have concluded that poor sleep quality and inflammaging worsen each other in a vicious cycle , reducing quality of life and fueling other age-related diseases. More than a peripheral link Chronic Inflammation Chronic…
CASM regulates lysosomal expansion and cell fate during senescence
Cellular senescence, a hallmark of aging, is accompanied by a striking expansion of the cell’s lysosomal compartment, yet the pathway leading to increased lysosomal content remains unresolved. Here, we demonstrate that the master lysosomal transcriptional regulator TFEB is activated during…
Anna Volkmer on building a research career around better conversations
Anna Volkmer on building a research career around better conversations Dementia Researcher Dementia Researcher Dr Anna Volkmer Dr Anna Volkmer spent 13 years working as a speech and language therapist before starting her NIHR funded doctoral research. People with dementia and their families wanted…
Pickleball injuries more common in women, older adults
Pickleball-related upper extremity injuries may be more common in older adults and women, according to results. “While [pickleball] offers significant health and social benefits, its surging popularity has been accompanied by a notable rise in injuries, especially among seniors. Importantly, our…
Lysergic Acid Diethylamide Induces Transcriptional Changes Opposing Signatures of Brain Ageing and Neurodegeneration
Lysergic acid diethylamide (LSD) induces transcriptional programmes in the rodent prefrontal cortex that oppose signatures of human brain ageing and neurodegeneration. In primary cortical cultures, LSD also attenuates amyloid‐β‐induced alterations. Consistent with the signature reversion principle…
H3K18 Lactylation in Degenerated Nucleus Pulposus Cells Suppresses CD248 Through Transcriptional and Post‐Translational Modifications to Promote Apoptosis and Extracellular Matrix Degradation
The high lactate levels in degenerated intervertebral discs promote lactylation of NP cells. H3K18la inhibits the synthesis of CD248 mRNA by recruiting SMARCA5 and promotes the protein degradation of CD248 through the ubiquitin–proteasome pathway, thereby inducing apoptosis of NP cells and…
Power Up Your Muscle, Genes, and Healthy Aging Potential
1. Whey Protein Plus Strength Training: Promising Gains for Older Adults A new systematic review in PubMed found that combining strength training with whey protein (but not HMB) led to consistent improvements in fat-free mass and grip strength for older adults with sarcopenia. Participants saw…
The Double-Edged Sword of Therapy-Induced Senescence in Cancer Treatment
The dominant forms of cancer therapy, chemotherapy and radiotherapy , induce senescence in cancer cells they cannot kill, as well as in non-cancerous cells exposed to the treatment. Entering the senescent state is a response to a high level of stress and damage that isn't sufficient to kill the…
Anti-Fibrotic Drug Rentosertib Reduces Proteomic Clock Age in Humans
Rentosertib is a TNIK inhibitor developed by In Silico Medicine in the course of the company's efforts to find drugs that can affect aging, shown to be anti-fibrotic, and thus recently in a phase 2 trial for the treatment of idiopathic pulmonary fibrosis . Here, the researchers provide evidence…
Save the parasites!
The world is full of tiny things that live off more charismatic hosts. Parasite ecologists say that these critters, too, are finally starting to get the conservation attention they deserve.
What do voice and drawings recorded during the MMSE add to its score? A multicenter multimodal deep learning study of dementia screening
The aim was to develop and validate a multimodal deep learning model integrating voice and drawing data collected during dementia screening and to evaluate the contribution of each modality to classifying cognitively normal, mild cognitive impairment, and dementia. A total of 1091 participants were…
Neural correlates of frailty and the development of a cerebral frailty risk score for dementia
Frailty is a multisystem clinical syndrome closely linked to cognitive aging, yet its relationship with brain pathology and contribution to neurological outcomes remain unclear. We examined neuroimaging correlates of frailty and evaluated their integrative impact on incident dementia within a…
Neuronal injury and inflammatory protein signatures of postoperative delirium and cognitive decline in older adults—combining insights from post-surgical and memory clinic cohorts
Plasma proteomics may offer novel characterization of the longer-term inflammatory and neuronal injury alterations in older adults undergoing elective surgery, and their relations to delirium and cognitive decline. We leveraged plasma protein data from N = 616 participants across two longitudinal…
Cytotoxic CD4+ exTregs expressing KLRG1 retain immunosuppressive function in cancer
The role of cytotoxic CD4+ T cells in cancer remains controversial, with both pro- and anti-tumor functionality described. Based on a prior observation that putatively cytotoxic KLRG1+ FoxP3- conventional T cells (Tconv) associated with tumor progression, we deeply investigated the phenotype and…
Life-course social mobility and depressive symptoms among older adults: evidence from the Longitudinal Ageing Study in India
Evidence linking socioeconomic mobility to depressive symptoms in older adults in low- and middle-income countries is limited. We examined childhood-to-adulthood socioeconomic position (SEP) mobility in India. The primary cross-sectional analysis used complete-case data from 30,358 adults aged ≥ 60…
Multidimensional 24-h activity patterns in relation to cognition and Alzheimer’s disease plasma biomarkers: a cross-sectional study
Beyond total volume, how physical activity is distributed, timed, and structured across the 24-h cycle may reflect aspects of brain aging missed by conventional measures. We examined how these activity dimensions relate to cognitive status, cognitive performance, and Alzheimer’s disease…
A genetic screen to identify host factors required for commensal bacterial adherence to the gut epithelia
Bacterial adherence to gut epithelial cells likely involves host genetic components. We isolated a gut commensal bacterium, Lelliottia jeotgali, that can robustly colonize C. elegans through attachment to intestinal epithelial cells. Here, we developed a novel screen in C. elegans to identify host…
The antagonism of sex chromosomes and sex hormones dictates outcomes in Th17 cell-mediated central nervous system autoimmunity.
Biological sex traits are shaped by the combined effects of both sex hormones and chromosomes. How these factors interact in sex-related autoimmune diseases, such as multiple sclerosis (MS), has been a subject of intense recent interest. Here, using the Four Core Genotype (FCG) mouse model, in…
Structural and functional characterization of polyclonal antibody responses reveals shared and distinct antigenic features of RSV and hMPV fusion proteins
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), members of the Pneumoviridae family, circulate widely and are leading causes of hospitalization for acute respiratory infections in infants and older adults. The viral fusion (F) protein in its prefusion (preF) conformation is the…
HCMV glycoprotein B, but not the pentameric complex, is a key target of antibody-mediated phagocytosis
Human cytomegalovirus (HCMV) is a leading infectious cause of birth defects globally with devastating fetal health outcomes, and there is currently no HCMV vaccine available. Glycoprotein B (gB) and the pentameric complex (PC) are immunodominant HCMV envelope proteins and candidates of interest in…
B cells dominate the heart immune infiltrate during chronic infectious cardiomyopathy
Recent advances in single-cell and spatially resolved multi-omics have revolutionised our understanding of the cellular and molecular niches governing cardiac homeostasis and acute injury. However, the immune-stromal networks sustaining long-term, chronic heart pathology remain poorly defined…
Body weight modifies the efficacy of lifespan-extending interventions in ad libitum-fed mice
Geroprotective interventions are often assessed by extension of lifespan in ad libitum-fed mice. Increased lifespan could therefore reflect rescue of adverse phenotypes of unhealthy controls. We analysed body weight and survival for 33,780 mice in the Interventions Testing Program (ITP) to test…
Single-nucleus analysis reveals renal STAT1/CEBPB signaling as a modifiable relay of proinflammatory FGF23 effects in diabetic kidney disease
Background Circulating fibroblast growth factor 23 (FGF23) rises dramatically in chronic kidney disease, particularly in diabetic kidney disease (DKD). At high concentrations, and with declining Klotho, FGF23 has been linked to renal inflammation. The cell types and transcriptional programs…
Cxcr2 is required for ductal outgrowth and shapes the stromal microenvironment in postnatal mammary gland development
Mammary gland development requires coordinated signaling between epithelial and stromal compartments. While CXC chemokine receptor 2 (CXCR2) is known to regulate inflammatory and tissue remodeling processes in disease, including breast cancer, its role in mammary gland morphogenesis is not well…
An architectural RNA builds a reaction crucible through molecular concentration and activated enzyme selection
Architectural RNAs (arcRNAs) scaffold membraneless organelles (MLOs), yet how they organize functional proteins remains unclear. Nuclear stress bodies (nSBs), MLOs scaffolded by HSATIII arcRNAs, incorporate SRSFs during stress. During stress recovery, nSBs function as reaction crucibles that…
Longitudinal CCR2 PET Imaging Tracks Early Inflammatory Monocyte and Macrophage Infiltration in Experimental Arthritis
Objective. Recruitment of C-C motif chemokine receptor 2 (CCR2+) inflammatory monocytes and macrophages represent an early event in rheumatoid arthritis (RA) pathogenesis that cannot be tracked noninvasively with existing imaging modalities. We evaluated longitudinal Ga-DOTA-ECL1i positron emission…
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